Teaming up with familiar faces to take down a sinister threat in the explosive conclusion of The Last Dose.
Rockstar Games finally released the second part of the two-part GTA Online DLC, The Lost Santos Drug Wars. If you haven't already, you must complete the first six missions of the DLC called The First Dose to get the second set of missions.
The second part of the DLC contains five missions and is called The Last Dose. It concludes the story which features characters like Dax, Labrat, Luchadora, and the infamous Isiah Friedlander from the Story Mode.
In this guide, we show you how to complete all five missions of The Last Dose. They're not difficult to complete, but they definitely require some form of preparation, including buying snacks and armor, as all missions contain a lot of combat.
To start The Last Dose missions, you must complete all six The First Dose missions. After completing the first six missions, you will receive a call from Dax.
After the call, you can start the mission by visiting 'D' outside the Freakshop. The letter 'D' represents Dax.
For the first mission, stocking up on armor and snacks would be best. After a lengthy introductory cutscene, you will be put into combat directly.
You will initially be in cover with several kidnappers trying to attack you from both sides of the Freakshop garage.
The mission is quite straightforward. You need to stay in cover and take out all the kidnappers. There's no time limit for this mission, so take your time.
Remember, the attackers will come from both sides of the garage. Once you've cleared one side, quickly run to the other and clear the kidnappers on the other side as well.
You will also notice attack choppers storming, once you've cleared one side. You can easily take them out by either eliminating the pilot or using a missile launcher. Use RPGs to take out vehicles. A minigun is also a good option.
Take advantage of the environment whenever you can. For instance, if you cannot target the enemies behind tankers, shoot them to cause an explosion and take out multiple enemies at once.
After a while, the kidnappers will start running away from the scene. At this point, take out the remaining enemies until you get a prompt to return to Dax. Do so to complete the mission.
In this mission, you must go to three different hideouts and take out all the enemies except their leader. You and Dax will interrogate the leader at each hideout to find out where the kidnappers took Labrat.
When you reach the first hideout, stay in cover and take out all the enemies. Once again, there is no time limit, so take your time.
The leader will be marked on your mini-map with a crown icon. Do not kill the leader, or the mission will fail.
Once you've eliminated all the enemies, approach the leader and wait for Dax to finish his dialogue.
Once done, you will repeat the same at the next hideout. The third hideout will be the final hideout. The leader at the third hideout will give you Elysian Islands as the location.
When you reach Elysian Islands, you must identify the warehouse where the kidnappers took Labrat.
You can easily identify it by finding the black car outside the warehouse. It is the same car used to take Labrat away in the first mission, This is an Intervention.
Approach the keypad and interact with it to hack it. This is the classic mini-game of aligning white highlighted blocks with the red passing line whenever they are in place. Align all the blocks to hack the warehouse doors.
Once you enter the warehouse, you need to find five clues. These clues are not marked for you initially. However, when you get close to them, they show up as a 'green camera icon' on your mini-map.
You need to take pictures of five key items inside this warehouse and send them to Dax. Here are the five clues.
Stack of military supply crates.
A pharmaceutical keycard on the workbench.
Medical supplies inside a wooden crate, just on the right of the workbench, with the pharmaceutical keycard.
The wooden pinboard on the wall with the picture of Dax, Labrat, and Luchadora next to the sofas.
A piece of a document on a red tools cabinet.
After capturing all five clues, two guards will appear in the warehouse. However, they won't be aware of your presence unless you walk into their cones of vision (you can check your mini-map to see their cones of vision).
You don't have to initiate an all-out attack on these guards. You can sneak past or take them out silently using a suppressed weapon. Alerting them will result in more enemies barging in.
After taking them out, return to the pharmaceutical keycard you took a picture of earlier and collect it.
After collecting the keycard, leave Elysian Island to complete the mission.
In this mission, you need to go to the pharmacy HQ you located in mission two and rescue Labrat. First, make your way to FriedMind HQ and use the pharmaceutical keycard to unlock the door and enter the HQ.
Once inside, make sure to switch to a suppressed weapon. You can always go in guns blazing, but sneaking in is much faster.
When you enter, you will find two guards directly ahead of you. Quickly take them both out with headshots.
Now, you will have the option to take the elevator to the top floor or use the stairs. Do not take the elevator, but go through the stairs.
When you go up the stairs, you will find a single guard standing by the door to the next stairwell.
Do not kill this guard yet. There are two more guards through the door, one of which will come through the door and next to the standing guard. Wait for the second guard to enter the door and then take out both guards together.
Go through the door, and you will find another guard facing away from you. Take him out and continue going up the stairs.
You will find another guard on his phone on your way upstairs. Take him out as well.
Finally, you will find two more guards next to the entrance of the top floor. Take them both out and proceed forward.
On this top floor, you must search for clues that may lead you to Labrat. There are two key items you need to collect here. The first is a clipboard with Labrat's picture on it. The second is the basement keys.
Once you reach the top floor, wait for the patrolling guard to return to the right side and take him out.
After taking the guard out, continue moving forward from the right side. Go through the office to the right and kill the scientist inside. Make sure to keep an eye out for the clipboard with Labrat's picture on it — it's on one of these desks or tables. The location is always random, but it will always be inside one of the offices on the top floor.
Continue to the next office ahead of you and eliminate the scientist inside. This is where we found the clipboard with Labrat's image during our playthrough.
Continue moving forward and enter the middle office. You will find one scientist inside here. Take him out silently as well.
Exit the middle office through the middle door. Do not continue going forward through the right side. Exit through the middle and turn right.
Wait for the patrolling guard to come outside of the next office and take him out.
Go inside the office, take out the scientist who is standing furthest away from you, and then shoot the one near you.
Fortunately, the keys to the basement were also on one of the tables inside this office. Again, it can be completely different for you.
Once you've collected the keys, make your way back to the stairwell and go all the way to the bottom. You will face some guards on your way down, but they're not too much of a hassle. Simply take them out and continue going down.
You will meet Luchadora at the bottom, next to the locked basement door. Unlock the door using the keys and enter the basement.
Inside the basement, you will come across some more enemies. Take them out, and a cutscene will play.
After the cutscene, you will be in a car, getting chased by the enemies. Drive back to the Freakshop to complete the mission.
In this mission, you need to face Isiah Friedlander at a rehab clinic. You will be asked to follow Dax to the location, but you don't have to follow him. You can simply mark the location and drive to the destination on your own.
When you get to the rehab clinic, kill all the enemies and go to the main entrance of the clinic, indicated with a yellow marker.
Upon hitting the yellow marker, you will be drugged, and a hallucinating combat event will start where you need to fight off multiple waves of different enemies.
You need to keep killing them and survive for as long as possible.
Eventually, when all the enemies disappear, shoot Dr. Friedlander on the balcony to start the next wave.
Keep repeating the same until you get a message to not fight at the bottom of your screen. You just need to let the enemies shoot and "kill you" to complete the mission.
For this mission, once again, we highly recommend stocking up on snacks and armor. This mission involves heavy combat.
First, you must get into the Velum and fly to the Los Santos International Airport.
When you get to the airport, you will notice a huge plane taking off. Get closer to the plane and start the hacking process.
Keep an eye on the progress bar in the right-hand corner of the screen. You need to stay in range until the bar fills up. You can also see the range indicated with a yellow circle on your mini-map.
Once the bar is completely filled, you will get a cutscene of you entering the plane.
When inside the plane, stay in cover and eliminate all the enemies.
Eliminate them all and make your way up to the cockpit.
When you get to the yellow marker at the end, you will enter the cockpit, and a cutscene will play.
Once the cutscene ends, you will assume control of the large plane. Fly it to Sandy Shores Airfield and land it there.
Luckily, you don't have to land it completely. You just have to get closer to the ground and the runway to initiate a cutscene of your landing.
After another cutscene, you will be stormed by cops. Now, you need to hold the cops off until Dax loads up the truck.
You can track how much cargo is loaded by looking at the progress bar above truck's health (at the bottom-right corner of the screen).
Once the truck is loaded, you need to get in the truck and deliver it to the Freakshop.
Make sure to take out the choppers if they do too much damage to the truck. Normally, you wouldn't need to worry about them as you can just drive to the destination, ignoring them. The choppers do not have a lot of health, so a few shots should do the job.
When you get close to the Freakshop, you will be asked to lose the cops. The best way to lose the cops is to get into the sewer. Luckily, the sewer entrance is near the Freakshop. Set the custom marker at the entrance of the sewer as shown in the map below and it will take you directly to the entrance. This is the same location we used during the Casino Heist to get away from the cops.
Go inside and then a bit deeper into the sewer, because the cops sometimes come in. Hide inside until you lose the cops.
After you lose the cops, deliver the truck to the Freakshop to complete the mission.
To start the Los Santos Drug Wars Last Dose mission, you must complete all six of The First Dose missions first. You will then get a call from Dax to start the next set of missions.
There are a total of 11 missions for the Los Santos Drug Wars DLC. The Last Dose has five missions and The First Dose has six missions.
